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KMID : 1123920070210041010
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 4 p.1010 ~ p.1016
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Herbal Cocktail Sagunja Protects -induced H9c2 Cardiomyoblast Cell Death through the Induction of Heme Oxygenase-1
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Park Chan-Hee
Moon Byung-Soon
Jeon Seon-Bok
Kim Nam-Song
Chung Sang-Young
Park Jin-Woo
Park Rae-Gil
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Abstract
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Sagunjatang (Sagunja), containing Radix Astragali, Radix Ginseng, Fructus Schizandrae, Radix Ophiopogonis and Radix Glycyrrhizae, has been used as a prescription for ischemic heart and brain diseases in Korean traditional medicine. This study was designed to investigate the protective mechanisms of Sagunja on -induced cytotoxicity of H9c2 cardiomyocytes. Treatment with resulted in death of H9c2 cells, characterized by apparent apoptotic features, including the fragmentation of nucleus and increase in sub-GO/G1fraction of cell cycle. However, Sagunja markedly suppressed the apoptotic characteristics of H9c2 cells induced by with decrease of intracellular peroxide level. In addition, Sagunja suppressed the features of mitochondrial dysfunction, including change of mitochondrial membrane potential, in - treated cells. Additionally, Sagunja induced the expression of HO-1 protein in both time-and dose-dependent manner. The role of HO-1 in ROS-scavenging activity of Sagunja is proposed
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KEYWORD
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protective effects, Sagunja, H9c2 cardiomyocytes, ROS, HO-1
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